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This is an annotated article example:
| PMID |
21140206 |
| Title |
IGFBP1
and IGFBP3
polymorphisms predict circulating IGFBP-3 levels among women
from high-risk breast cancer
families. |
| Author List |
Rosendahl AH, Hietala M, Henningson M, Olsson H, Jernström
H |
| Journal |
Breast Cancer Res Treat |
| Publication Date |
2010 Dec 8 |
| Abstract |
The insulin-like
growth factor (IGF)
pathway has been implicated as risk modifier in premenopausal breast cancer. In this study, associations
between single nucleotide polymorphisms (SNPs) and diplotypes in
the IGFBP1 and IGFBP3 genes and circulating
IGFBP-3 levels, BRCA family status and
breast cancer among women from high-risk breast cancer families
were investigated. Nine IGFBP1 and IGFBP3 SNPs were genotyped with PCR-based methods in 323 women. Nine IGFBP1 and ten IGFBP3 diplotypes were identified. Plasma IGFBP-3 levels
obtained during cycle day 18-23 were
available for 231 women, 87 current users of combined oral
contraceptives and 144 non-users. IGFBP1 (rs1995051
and rs4988515) and IGFBP3 (rs2471551 and rs2854744)
SNPs were associated with circulating IGFBP-3 levels (P < 0.05). IGFBP1 (low)
diplotypes were associated with lower IGFBP-3 levels and were more common in BRCA2 families OR 2.05 (95%CI
0.97-4.30). IGFBP3 (high) diplotypes were associated
with higher IGFBP-3
levels and were more common in BRCAX
families OR 1.68 (95%CI 1.04-2.74). After adjusting the models for
BRCA family status,
both the BRCA1 and BRCA2 family status (P ≤ 0.006) and the IGFBP1 diplotype GTAC/ACAT
(P = 0.004) were
associated with lower IGFBP-3
levels. Similarly, both the BRCA1
and BRCA2 family status
(P ≤ 0.03) and the IGFBP-3
diplotypes GCA/GCG (P = 0.007) and GCG/CCG
(P = 0.002) were significantly associated with lower IGFBP-3 levels, adjusted for
age, weight, OC use, and
other IGFBP diplotypes.
No individual SNP was associated with breast cancer. There were 23 cases of breast cancer and one IGFBP1 diplotype
was associated with a decreased risk of breast cancer
after age 18 (log rank P=0.05). In
conclusion, independent effects from IGFBP1, IGFBP3 diplotypes,
and BRCA family status on IGFBP-3 levels were observed. These factors may influence the risk of breast
cancer among women from
high-risk breast cancer
families. |
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